Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse
نویسندگان
چکیده
As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.
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متن کاملAWARD NUMBER: W81XWH-13-1-0341 TITLE: “Delivery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse” PRINCIPAL INVESTIGATOR:
Purpose: The purpose of this study is to develop an alternate empirical approach to estimate near-infra-red (NIR) photonpropagation and quantify optically induced drug release in brain metastasis, without relying on computationallyexpensive Monte Carlo techniques (gold standard). Targeted drug delivery with optically induced drug release is a non-invasive means to treat cancers and ...
متن کاملAWARD NUMBER: W81XWH-13-1-0342 TITLE: Delivery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse PRINCIPAL INVESTIGATOR:
Purpose: The purpose of this study is to develop an alternate empirical approach to estimate near-infra-red (NIR) photonpropagation and quantify optically induced drug release in brain metastasis, without relying on computationallyexpensive Monte Carlo techniques (gold standard). Targeted drug delivery with optically induced drug release is a non-invasive means to treat cancers and ...
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